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Core Nutritionals BURN Innovative Multi-stage Thermogenic 150 Capsules
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List Price: $69.99
Your Price: $44.99
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Core Nutritionals BURN Innovative Multi-stage Thermogenic - 50 Servings |
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Every week, there is a new story about a "breakthrough" or "miracle"
substance that will make every other ingredient before it obsolete. Some
of these claims may have merit, but the truth is that the biochemical
processes of lipolysis are very complex and tightly regulated by the
endocrine system and other biochemical pathways. Navigating this maze to
effectively manage weight and body composition therefore requires more
than a single, "miracle" compound: it involves numerous agents that
together activate certain metabolic functions, while suppressing others.
No single, "magic" compound does the job alone.
Core BURN is formulated to drop the kitchen sink and "miracle"
ingredient tactics, and instead uses a diverse range of proven
ingredients to create a powerful, balanced, and effective product.
Core BURN is designed to target precise primary and secondary
metabolic pathways, at multiple targets, to ensure maximum
effectiveness. No more playing darts in the dark when it comes to weight
management categories; randomly including ingredients, in whatever
servings, hoping that something works. Specific. Multi-targeted. These
words exemplify the new approach: amazing ingredients, in
clinically-reflected serving sizes, all included in a non-proprietary
blend so you know exactly what you’re consuming.
Acetyl-l-Carnitine
L-carnitine is a derivative of the amino acid lysine and, as certain
conditions outpace the body’s ability to produce it, l-carnitine is
considered a conditionally essential amino acid. While endogenous
biosynthesis of l-carnitine from the amino acids lysine and methionine
is sufficient for essential processes – along with dietary sources of
carnitine from protein-rich red meat, for example – dietary
supplementation of carnitine may pose benefits in certain physiological
conditions.
Unfortunately, due to excess metabolism of l-carnitine by microorganisms
in the small intestine, exogenous supplementation with oral l-carnitine
has proved ineffective. ALCAR, an acetylated version of l-carnitine, has
considerably higher oral bioavailability, due likely to only partial
hydrolytic metabolism. Once in the bloodstream, ALCAR plays a
fundamental role in the production of energy, acting as the catalyst for
the beta-oxidation of long chain fatty acids by the mitochondria;
regulating the CoA to Acyl-CoA ratio (necessary for the production of
ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory
agent for neurons, increases neuronal transmission, and increases the
production of neurotransmitters and neurohormones such as dopamine and
serotonin.
Green Tea Extract (Camilla sinensis) (leaf) (50% EGCG)
Along with caffeine from the coffee plant, EGCG (Epigallocatechin
gallate) from various sub-species of Camilla sinesis (green tea) is
perhaps the most widely known and reputable anti-lipogenic and lipolytic
agent in the world. Both compounds have well established anti-obesity
effects, detailed in a deep body of literature featuring in vitro cell
culture, as well as in vivo animal and human trials.
In animal and human studies, green tea generally and EGCG more
specifically has been demonstrated to reduce the absorption of dietary
lipids and modulate their subsequent metabolism, increase glucose
utilization in resting states, as well as initiate de novo lipogenesis
in both maximal and submaximal exercise states.
A two month dietary intervention, for example, showed that the daily
consumption of a catechin-rich tea – EGCG is the most well-known of the
catechins – by healthy humans led to a reduction of bodyweight of up to
20%, the consequence of increased lipolysis (as measured by FFA urinary
clearance). A separate double-blind, placebo controlled trial using EGCG
consumption both with, and without caffeine, demonstrated the increased
oxidation of fatty acids within two hours of a meal – at level increases
of 49% and 35%, respectively.
These studies suggest that EGCG not only exerts an inhibitory effect on
the accumulation of lipids, but that it perhaps actively leads to the
hydrolyzation of triglycerides for use as energy in the form of FFAs. In
particular, this effect seems to be potentiated in the presence of
caffeine ingestion, suggesting a synergistic effect between EGCG and
caffeine on the hydrolyzation and subsequent oxidation of triglyceride
stores.
Green Coffee Extract (Coffee arabica) (bean) (50% chlorogenic acid)
Chlorogenic acids (CGAs) are phenolic compounds created during the
metabolism of various isoquinic acids found in the leaves of both coffee
and tea. In addition to the well-established sympathomimetic effects of
coffee and tea’s constituents, recent research has demonstrated a range
of other potential benefits for compounds such as chlorogenic acids.
Recent literature suggests that the consumption of both green coffee, as
well as standardized extracts of CGAs, relax the vasculature and improve
vasoreactivity, impose an inhibitory effect on lipid accumulation and
body weight in both mice and humans, and modulate glucose metabolism via
the glucose-6-phosphate pathway.
Trials in both humans and mice using 1% extracts of green coffee bean
revealed significant bodyweight reductions over periods of two and eight
weeks. Researchers hypothesized that the bodyweight reductions
associated with oral CGA administration was associated with the products
numerous mechanisms of action, rather than a single, isolated cause.
Olive Extract (Olea europaeai) (leaf) (20% oleuropein)
Olea europaea, more commonly known as the olive, is a species of a small
tree in the family Oleaceae, native to the coastal areas of southeastern
Europe, western Asia and northern Africa, as well as northern Iran at
the south end of the Caspian Sea.
As the fruits, oils, and extracts of Olea europaea L. are a dietary
component for a significant portion of the world’s population, the plant
has become associated with a wide-range of physiologic and metabolic
benefits. These properties are largely attributed to the phenolic
compounds of olive leaves, including: caffeic acid, verbascoside,
oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and
luteolin 4′-O-glucoside. Collectively, these olive polyphenols are
responsible for a wide-range of postulated health benefits.
Oleuropein, in particular, is purported to have several pharmacological
properties including antioxidant, anti-inflammatory, anti-atherogenic,
and anti-microbial effects. Recent research in animals has also
demonstrated that oleuropein may potentiate the response of
5'-deiodinase, the enzyme responsible for the irreversible conversion of
thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.
Caffeine (1,3,7-trimethylxanthine) and Theomobrine
(3,7-dimethyl-1H-purine-2,6-dione)
Caffeine is the most widely consumed, and perhaps one of the most
reviewed, psychoactive compounds. Its physiological effects in a range
of areas have been well-documented, including exercise performance,
information processing, alertness and mood enhancement, attention, and
awareness, along with its anti-lipogenic and lipolytic abilities.
Caffeine is also the most well-known in the methylxanthine compound
class, the constituents of which inter-metabolize into one another in
the human body and largely share similar effects.
Various clinical trials have demonstrated that xanthines – including
caffeine and theobromine – exert potent lipolytic (the breakdown of
triglycerides into fatty acids) and oxidative actions as sympathomimetic
amines. In less scientifically-complex parlance, this means caffeine is
forcing your body to preferentially use adipose tissue as a fuel source
for the oxidative provision of ATP (your body’s energy currency).
Evidence for xanthine’s capacity as lipolytic agents is widely
available. In a clinical study featuring four separate trials in both
normal and obese subjects, for example, caffeine was found to
significantly increase fatty acid metabolism (as measured by serum fatty
acid concentration), resting metabolic rate, and total fat oxidation –
suggesting the preferential substrate selection spoken about above
occurs in both normal and obese individuals. Other trials have
demonstrated the effects of methylxanthines on total fat mass
(reduction), lean body mass (increases), stamina and endurance, as well
as cardiovascular capacity.
Additionally, as selective cAMP potentiators, through the
beta-adrenergic pathway, caffeine and theobromine have been hypothesized
to exert a synergistic effect on lipolysis when combined with forskolin.
Bacopa monnieri Extract (whole plant) (50% bacosides)
Bacopa monnieri (BM), also known as the water hyssop commonly, or as
Brahmi in Ayurvedic texts, is a small creeping herb endemic to
sub-tropical India. The herb has been used in traditional Indian
medicine for well over one thousand years, with its first recorded usage
coming in the 6th century A.D. In this traditional context, BM has been
used for a wide-range of purposes, including as a treatment of asthma
and epilepsy.
More recently, BM has been the subject of numerous cognition and memory
trials, as the plant has a well-established nootropic effect. Likely
through modulation of the serotonin reuptake system, clinical trials in
healthy human beings have demonstrated that BM possesses a significant
effect on the retention of newly-learned information. In several trials
utilizing a 300mg daily serving, BM was also shown to decrease the
recall delay of newly learned information and reduce short term
forgetfulness – suggesting that the herb’s effect on the serotonic and
cholinergic systems are increasing the encoding (the literal storing) of
memory information.
Beyond cognition and memory encoding, BM has also been demonstrated to
function as a potent adaptogen and relaxant – which in the Core BURN
formula may help to smooth the effect curve of the product’s stimulants,
reducing jitteriness or "crash."
ForsLean® (Coleus forskohlii) (root) (20% forskolin)
Coleus forskohlii is a small perennial endemic to various tropical
regions in the world, including South America, sub-Saharan Africa, and
India. While the West has recently taken interest in the plant due to
the pharmacological properties of its primary bioactive, forskolin,
Coleus forskholii preparations and tinctures have been used in both
South American and African traditional folk medicinal systems, as well
as extensively within Ayurveda.
Due to the ever-increasing interest in the plant’s verifiable
pharmacological and physiological effects, however, Coleus forksholii
and its extracted constituents have been the subject of numerous animal
and human clinical trials in the past decade, primarily in its patented
form of ForsLean. These trials have demonstrated the plant to have
various effects and applications, including as a lipolytic and anti-lipogenic,
and as a powerful antioxidant.
A recent double-blind, randomized, and placebo-controlled human clinical
trial featuring obese men found that the daily implementation of
ForsLean, for twelve weeks, led to significantly better weight loss
outcomes as compared to controls. Overweight men in the ForsLean group
experienced not only improved body composition (as measured by total
non-lean mass), but also statistically significant increases in lean
body mass.
In a separate 8 week trial, in overweight females, ForsLean was found to
significantly reduce total bodyweight and significantly increase lean
body mass relative to controls. Weight loss was statistically
significant after 4 and 8 weeks and the mean amounted to 4.3 and 9.17
lbs respectively.
ForsLean – and more specifically, forskolin – achieves this effect by
rapidly, potently, and dose-dependently increasing an important
metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an
enzyme responsible for catalyzing the formation of cyclic adenosine
monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in
cAMP formation eventually leads to the activation of an enzyme, protein
kinase A, which in turn will phosphorylate and hence activate the
enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme
necessary for stored triglycerides within adipocytes to be released as
free fatty acids and utilized for energy.
In more basic terms, this means that forskolin quite literally frees up
more fatty acids to be used as fuel for exercise – more or less the
perfect scenario in a product such as Core BURN!
Yohimbe Extract (Pausinystalia yohimbe) (bark) (8% Yohimbine
alkaloids)
Extracts or preparation of Pausinystalia yohimbe, and related
sub-species, have been used in traditional and folk medicinal systems
such as Ayurveda and Unani for centuries. More recently, the principal
bioactive compound in Pausinystalia yohimbe, both as a whole plant, and
its extracted components, has been the subject of numerous clinical
trials investigating its various physiological pathways.
In particular, recent research has shown that yohimbe bark extracts
exert a powerful pre-synaptic inhibiting effect on alpha-adrenergic
receptors – making it a potent adrenergic antagonist. This effect seems
to be localized and largely specific to adipocytes, attaching to their
adrenergic receptor sites and preventing them from receiving the
catecholamines (norepinephrine and epinephrine) that would normally
initiate growth signals.
While limited, there is some evidence in human, clinical trials to
suggest that Yohimbine’s postulated mechanisms of action translate into
practical effects. In a placebo-controlled trial involving 20 healthy,
lean soccer players, subjects were given 20mg/day in two equal servings,
for 21 days. At 21 days, the Yohimbine group reflected small but
significant reductions in both total fat mass and bodyfat percentage as
compared to controls – at least partially suggesting that Yohimbine may
have a plausible role in combination with diet and exercise in weight
management.
Advantra-Z® Bitter Orange Extract (Citrus aurantium) (fruit) (50%
synephrine)
Synephrine is a naturally-occurring alkaloid with adrenergic agonist
activity, structurally related to epinephrine, norepinephrine,
ephedrine, and other compounds with a phenethylamine base structure.
Despite its chemical similarity to these compounds, synephrine in its
various isomers exerts unique effects on adrenergic receptors, in
particular, and the human body, in general.
Synephrine exists in three isomer forms: para-, meta- and
ortho-synephrine. The molecular changes between the three isoforms are
minute, but even this small change results in significant alterations to
each isomer’s physiological and pharmacokinetic profile. Two of
synephrine’s isomers, both p- and m-synephrine, have been shown to
naturally occur in mammals (in low concentrations). As a sympathomimetic,
synephrine has been the subject of numerous trials, assessing its
effects on weight management, thermogenesis, metabolic rate, and caloric
expenditure. In a double-blind, randomized, and placebo-controlled trial
involving 10 healthy individuals, the p-synephrine isomer was
administered at a 50mg serving, both alone, and in combination with
hesperidin and naringin. The authors measured resting metabolic rate (RMR),
blood pressure, and heart rate, along with subjective feelings of mood
and energy, at baseline, and at 45-mintues and 75-minutes after
ingestion. The authors reported a significant increase in RMR in each of
the supplement groups, relative to placebo.
In addition to studies on synephrine in its various isomers, Advantra-Z®,
the specific form of synephrine utilized in Core BURN, has itself and in
combination with other ingredients, been the subject of various clinical
trials in humans. In a randomized, double-blind, placebo-controlled
trial featuring 70 obese adults, a formulation containing Advantra-Z®
was found to significantly reduce fat mass, body weight, and hip and
waist girth as compared to controls, while leading to an increase in
lean mass. As the authors comment, these results are in-line with a
recent systematic review of human clinical studies involving Citrus
aurantium, that revealed the ingredient to reliably increase resting
metabolic rate up to 7.2%, increase energy expenditure of up to 13.4%,
and weight loss of over 2.9 kg, with no serious adverse events in any of
the trials.
In addition, the combination of caffeine and synephrine appears to
potentiate each ingredient’s effects – with rates of fatty acid
liberation, heart rate, metabolic rate, and fatty acid oxidation
increased in clinical trials featuring the combination. In the same
systematic review mentioned above, the authors note that the combination
of synephrine and caffeine led to a small but significant reduction in
fat mass of 3lbs, and a reduction in bodyfat of 2.9%.
Combined with not only caffeine, but the other ingredients in Core BURN,
Advantra-Z® appears to be a potent weapon in the arsenal for body
composition and weight management. |
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| *These statements have not been evaluated by the Food & Drug
Administration. This product is not intended to diagnose, treat, cure or
prevent any disease. |
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